Trifluoroacetic acid → Trifluoroacetic acid

HRID 42183노트

반응식

HRID 42183 반응식
[CH3:1][O:2][C:3]([C:5]1[CH:6]=[N:7][C:8]([N:11]2[CH2:16][CH2:15][N:14](C(OC(C)(C)C)=O)[CH2:13][CH2:12]2)=[N:9][CH:10]=1)=[O:4].[F:24][C:25]([F:30])([F:29])[C:26]([OH:28])=[O:27]>ClCCl>[CH3:1][O:2][C:3]([C:5]1[CH:10]=[N:9][C:8]([N:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)=[N:7][CH:6]=1)=[O:4].[C:26]([OH:28])([C:25]([F:30])([F:29])[F:24])=[O:27]

참가 물질

5

반응물 2

HCID 6422Trifluoroacetic acidHCID 59240679Methyl 2-(4-(tert-butoxycarbonyl)piperazin-1-yl)pyrimidine-5-carboxylate

생성물 2

HCID 6422Trifluoroacetic acid수율 262.7%HCID 57471612Methyl 2-(piperazin-1-yl)pyrimidine-5-carboxylate

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

2-(4-tert-Butoxycarbonyl-piperazin-1-yl)-pyrimidine-5-carboxylic acid methyl ester (140 mg, 0.434 mmol) is dissolved in dichloromethane (3.0 mL) under N2. Trifluoroacetic acid (0.83 ml, 10.85 mmol) is added and the reaction mixture is stirred for 2 h. The reaction mixture is concentrated under reduced pressure and co-evaporated several times with dichloromethane. It is dried under high vacuum to afford the title compound as a TFA salt (130 mg, 90% yield).

후처리

  1. concentrationThe reaction mixture is concentrated under reduced pressure
  2. customIt is dried under high vacuum

출처 및 근거

ORD 기록
ord-f0ad376f7fb445229dc8392f8c020b6f
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536168B2

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