Thioacetamide → HCID 66673711, 화합물

HRID 421835노트

반응식

HRID 421835 반응식
[C:1]([NH2:4])(=[S:3])[CH3:2].Br[CH2:6][C:7]([N:9]1[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]1)=O>C(O)C>[CH3:2][C:1]1[S:3][CH:6]=[C:7]([N:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)[N:4]=1

참가 물질

4

반응물 2

HCID 2723949ThioacetamideHCID 15829155tert-Butyl 4-(bromoacetyl)piperazine-1-carboxylate

생성물 1

HCID 66673711HCID 66673711, 화합물수율 2.2%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

Thioacetamide (120 mg) was added to an ethanol (6 mL) solution of tert-butyl 4-(bromoacetyl)piperazinecarboxylate (340 mg) obtained in the above 1), and heated under reflux for 3 hours. The reaction liquid was restored to room temperature, then the solvent was evaporated away under reduced pressure, and the resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=7/3) to obtain 7 mg of the entitled compound.

후처리

  1. customobtained in the above 1), and
  2. temperatureheated
  3. temperatureunder reflux for 3 hours
  4. customThe reaction liquid
  5. customwas restored to room temperature
  6. customthe solvent was evaporated away under reduced pressure
  7. customthe resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=7/3)

출처 및 근거

ORD 기록
ord-5049bb1cc5e24c538645131813f4771e
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101618B2

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