Phosphorus oxychloride → Methyl 4-chloro-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate

참여 물질

역할	이름	HCID	투입량
반응물	Phosphorus oxychloride	HCID 24813	—
반응물	Methyl 1,6-dihydro-4-hydroxy-6-oxo-1-phenyl-3-pyridazinecarboxylate	HCID 54686161	—
생성물	Methyl 4-chloro-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylate	HCID 2784479	84%

반응 조건

온도	85 °C

반응 단계

A mixture of 4-hydroxy-6-oxo-1-phenyl-1,6-dihydropyridazine-3-carboxylic acid methyl ester (3.83 g, 15.6 mmol) and phosphorous oxychloride (50 mL) was heated to 85° C. After 20 hours, the reaction mixture was concentrated under reduced pressure. The resulting residue was quenched with water. The precipitate was filtered and dissolved in EtOAc, dried (MgSO4) and concentrated under reduced pressure to yield 3.44 g (84%) of desired product.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08101611B2
출처 데이터셋	uspto-grants-2012_01
ORD ID	ord-0d539a506ef44539957b92ef876d0d1a
출처 메모	uspto-grants-2012_01