Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethyl 6-chloronicotinate → Ethyl 6-[(2R)-2-methyl-4-[4-(phenylmethyl)-1-phthalazinyl]-1-piperazinyl]-3-pyridinecarboxylate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethyl 6-chloronicotinate | HCID 2799611 | — |
| 반응물 | 1-Benzyl-4-((R)-3-methyl-piperazin-1-yl)-phthalazine | HCID 44186248 | — |
| 생성물 | Ethyl 6-[(2R)-2-methyl-4-[4-(phenylmethyl)-1-phthalazinyl]-1-piperazinyl]-3-pyridinecarboxylate | HCID 59240661 | 71.1% |
반응 단계
Following the above procedure, 6-chloronicotinic acid ethyl ester (100 mg, 0.54 mmol, 1.7 eq) and 1-benzyl-4-((R)-3-methyl-piperazin-1-yl)-phthalazine (100 mg, 0.31 mmol, 1.0 eq) afford the title compound as a white solid (103 mg, 71% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536168B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-526bb1fb44604fb196db5f4a9db53633 |
| 출처 메모 | uspto-grants-2013_09 |