Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 421941생성일: 2026년 10월 26일
Methyl 2-chloroacrylate → Dimethyl 13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzoxazepine-6,10-dicarboxylate
https://huagongshe.com/reaction/421941
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Methyl 2-chloroacrylate | HCID 6659 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | N-Butyltriethylammoniumchloride | HCID 10888803 | — |
| 반응물 | Methyl 3-cyclohexyl-2-(2-hydroxyphenyl)-1H-indole-6-carboxylate | HCID 11995228 | — |
| 용매 | Acetonitrile | HCID 6342 | — |
| 생성물 | Dimethyl 13-cyclohexyl-6,7-dihydroindolo[1,2-d][1,4]benzoxazepine-6,10-dicarboxylate | HCID 66674678 | 81% |
반응 단계
Methyl chloroacrylate (1.7 eq.), triethylbutyl ammonium chloride (0.2 eq.) and K2CO3 (6 eq.) were added to a solution of methyl 3-cyclohexyl-2-(2-hydroxyphenyl)-1H-indole-6-carboxylate (prepared as described in International patent application publication W02006/046030, Example 9) in anhydrous MeCN (0.02 M). The mixture was heated at 60° C. overnight and then allowed to cool to RT. Volatiles were removed in vacuo, diluted with EtOAc, washed with water, dried (Na2SO4), filtered and concentrated in vacuo. The crude product was purified by FC (EtOAc/PE 10:90) to afford the product as a solid (81%). (ES+) m/z 434 (M+H)+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08101595B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_01 |
|---|
| ORD ID | ord-9ff26440d4e44c6f96d59fbb251938f3 |
|---|
| 출처 메모 | uspto-grants-2012_01 |
|---|
