참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | 2-(Dicyclohexylphosphino)biphenyl | HCID 2734216 | — |
| 반응물 | 1-Benzyl-4-piperazin-1-yl-phthalazine | HCID 6404023 | — |
| 반응물 | Potassium tert-butoxide | HCID 23665647 | — |
| 반응물 | 2-(6-Chloro-pyridin-3-yl)-1-pyrrolidin-1-yl-ethanone | HCID 57471614 | — |
| 촉매 | palladium(II) acetate | HCID 167845 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | HCID 59240555 | HCID 59240555 | — |
반응 단계
To a solution of this amide (0.22 g, 1 mmol) and 1-benzyl-4-piperazin-1-yl-phthalazine (0.15 g, 0.5 mmol) in toluene (10 mL) were added (2-biphenyl)dicyclohexyl phosphine (35 mg, 0.1 mmol), Pd(OAc)2 (11 mg, 0.05 mmol) and KOtBu (336 mg, 3 mmol). The mixture was degassed and then heated in a microwave reactor at 90° C. The reaction mixture was cooled to room temperature and filtered. Water was added to the filtrate and extracted with EtOAc. The combined organic layers were washed with water, sat. NaHCO3, brine, dried over Na2SO4, filtered and concentrated.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08536168B2 |
|---|
| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-3d0271881ab04280b77fec1a26ed43cb |
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| 출처 메모 | uspto-grants-2013_09 |
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