Triethylamine → 6-[4-(4-Chloro-phthalazin-1-yl)-piperazin-1-yl]-nicotinic acid ethyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Triethylamine	HCID 8471	—
반응물	N-methyl-2-pyrrolidone	HCID 13387	—
반응물	1,4-Dichlorophthalazine	HCID 78490	—
반응물	Ethyl 6-(piperazin-1-yl)nicotinate	HCID 14987933	—
용매	Water	HCID 962	—
생성물	6-[4-(4-Chloro-phthalazin-1-yl)-piperazin-1-yl]-nicotinic acid ethyl ester	HCID 57471616	49%

반응 단계

Combine 6-piperazin-1-yl-nicotinic acid ethyl ester (1.30 g, 5.40 mmol), 1,4-dichlorophthalazine (932 mg, 4.59 mmol), triethylamine (1.78 mL, 13.50 mmol), and NMP (8 mL) and heat to 85° C. for 6 h. Cool to room temperature, dilute with H2O (50 mL) and extract organics with EtOAc (3×50 mL). Combined organic layers are dried over MgSO4 and concentrated. Resulting solid is triturated with EtOAc to give the title compound as a fine tan powder (895 mg, 49% yield).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08536168B2
출처 데이터셋	uspto-grants-2013_09
ORD ID	ord-1f3c4c1675544c09b427902408c8625c
출처 메모	uspto-grants-2013_09