Water → 5-(3-methyl-4-nitrophenyl)furo[3,2-c]pyridin-4(5H)-one

HRID 422079

반응식

HRID 422079 반응식
F[C:2]1[CH:7]=[CH:6][C:5]([N+:8]([O-:10])=[O:9])=[C:4]([CH3:11])[CH:3]=1.[O:12]1[C:20]2[CH:19]=[CH:18][NH:17][C:16](=[O:21])[C:15]=2[CH:14]=[CH:13]1.C([O-])([O-])=O.[Cs+].[Cs+].O>CN(C=O)C>[CH3:11][C:4]1[CH:3]=[C:2]([N:17]2[CH:18]=[CH:19][C:20]3[O:12][CH:13]=[CH:14][C:15]=3[C:16]2=[O:21])[CH:7]=[CH:6][C:5]=1[N+:8]([O-:10])=[O:9]

참가 물질

6

반응물 4

HCID 962WaterHCID 10796Cesium carbonateHCID 949565-Fluoro-2-nitrotolueneHCID 2887464H,5H-furo(3,2-c)pyridin-4-one

생성물 1

HCID 580155665-(3-methyl-4-nitrophenyl)furo[3,2-c]pyridin-4(5H)-one수율 108.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
125 °C

실험 절차

4-Fluoro-2-methyl-1-nitrobenzene (2.3 mL, 19 mmol) was added to a suspension of furo[3,2-c]pyridin-4(5H)-one (2.115 g, 15.67 mmol) and Cs2CO3 (5.097 g, 15.67 mmol) in anhydrous DMF (100 mL) and the resulting suspension was heated to 125° C. and stirred for 15 h. H2O was added and the aqueous suspension was filtered. The solid was dried under reduced pressure to afford 4.6 g of crude 5-(3-methyl-4-nitrophenyl)furo[3,2-c]pyridin-4(5H)-one, which was used without further purification.

후처리

  1. filtrationthe aqueous suspension was filtered
  2. customThe solid was dried under reduced pressure

출처 및 근거

ORD 기록
ord-38672bfa8ebe4c00a85c3504a8040464
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101632B2

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