2-Chloromethyl-imidazo(1,2-A)pyridine → Imidazo(1,2-a)pyridine

HRID 422278노트

반응식

HRID 422278 반응식
ClC[C:3]1[N:4]=[C:5]2[CH:10]=[CH:9][CH:8]=[CH:7][N:6]2[CH:11]=1>C([O-])(O)=O.[Na+]>[N:4]1[CH:3]=[CH:11][N:6]2[CH:7]=[CH:8][CH:9]=[CH:10][C:5]=12

참가 물질

3

반응물 1

HCID 9576142-Chloromethyl-imidazo(1,2-A)pyridine

생성물 1

HCID 78960Imidazo(1,2-a)pyridine수율 80%

시약·촉매·용매 1

HCID 516892Sodium Bicarbonate용매

실험 절차

To saturated NaHCO3 (40 mL) was added the chlorhydrate form of 2-(chloromethyl)-imidazo[1,2-a]pyridine and the aqueous layer was extracted with AcOEt. The organic layers were combined and washed with brine, dried over MgSO4 and the solvent was removed under reduced pressure to afford 877 mg of 2-chloromethyl)-imidazo[1,2-a]pyridine (Yield. 80%) as a brownish solid (M.P.: 8485° C.)

후처리

  1. extractionthe aqueous layer was extracted with AcOEt
  2. washwashed with brine
  3. dry with materialdried over MgSO4
  4. customthe solvent was removed under reduced pressure

출처 및 근거

ORD 기록
ord-87acddfc0a9e4ecc9b0e7604d463773c
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101637B2

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