HCID 66597907, 화합물 → HCID 86086783, 화합물

반응식

[Cl:1][C:2]1[C:10]2[C:6](=[CH:7][N:8]([CH2:11][CH2:12][C:13]#[C:14][Si](C)(C)C)[N:9]=2)[CH:5]=[CH:4][CH:3]=1.ClC1C=CC=C2C=1N(CCC#C[Si](C)(C)C)N=C2>>[CH2:11]([N:8]1[CH:7]=[C:6]2[C:10]([C:2]([Cl:1])=[CH:3][CH:4]=[CH:5]2)=[N:9]1)[CH2:12][C:13]#[CH:14]

참가 물질

반응물 2

HCID 66597907HCID 66597907, 화합물

HCID 66598304HCID 66598304, 화합물

생성물 1

HCID 86086783HCID 86086783, 화합물수율 23%

실험 절차

The title compound was prepared in accordance with the general method of Example 108(B), from 7-chloro-2-(4-trimethylsilanyl-but-3-ynyl)-2H-indazole and 7-chloro-1-(4-trimethylsilanyl-but-3-ynyl)-1H-indazole (250 mg, 0.90 mmol). The crude residue was purified by flash chromatography (cyclohexane/AcOEt 9:1) to yield 44 mg (0.21 mmol, 23%) of 2-(but-3-ynyl)-7-chloro-2H-indazole as an orange oil.

후처리

customThe crude residue was purified by flash chromatography (cyclohexane/AcOEt 9:1)

출처 및 근거

ORD 기록: ord-9a758e15dd584968b67f309a4ea77635
출처 데이터셋: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08101637B2

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