Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline → 4-Methyl-3-(1-(1,1,1-trifluoropropan-2-yloxy)phthalazin-6-yl)benzenamine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 4-Methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline | HCID 16086089 | — |
| 반응물 | Phthalazine, 6-chloro-1-(2,2,2-trifluoro-1-methylethoxy)- | HCID 66675982 | — |
| 생성물 | 4-Methyl-3-(1-(1,1,1-trifluoropropan-2-yloxy)phthalazin-6-yl)benzenamine | HCID 66675739 | — |
반응 단계
The title compound was prepared according to a procedure similar to that described in Example 225, using 6-chloro-1-(1,1,1-trifluoropropan-2-yloxy)phthalazine and 4-methyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine as starting materials. MS (ESI, pos. ion) m/z: 348.1 (M+1). The racemic material was subjected to Preparative SFC separation using a chiral column to afford its (R)- and (S)-enantiomers.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08101612B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-e31646723b8647f9bac97b0a8f9b1c35 |
| 출처 메모 | uspto-grants-2012_01 |