Ethyl isocyanate → HCID 11612890, 화합물

HRID 422624노트

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HRID 422624 반응식
[NH2:1][C:2]1[C:3]2[N:4]([C:8]([CH:27]3[CH2:32][CH2:31][N:30]([C:33](=[O:35])C)[CH2:29][CH2:28]3)=[N:9][C:10]=2[C:11]2[CH:20]=[C:19]3[C:14]([CH:15]=[CH:16][C:17]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[N:18]3)=[CH:13][CH:12]=2)[CH:5]=[CH:6][N:7]=1.[CH2:36]([N:38]=C=O)[CH3:37]>>[NH2:1][C:2]1[C:3]2[N:4]([C:8]([CH:27]3[CH2:28][CH2:29][N:30]([C:33]([NH:38][CH2:36][CH3:37])=[O:35])[CH2:31][CH2:32]3)=[N:9][C:10]=2[C:11]2[CH:20]=[C:19]3[C:14]([CH:15]=[CH:16][C:17]([C:21]4[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=4)=[N:18]3)=[CH:13][CH:12]=2)[CH:5]=[CH:6][N:7]=1

참가 물질

3

반응물 2

HCID 8022Ethyl isocyanateHCID 11677004HCID 11677004, 화합물

생성물 1

HCID 11612890HCID 11612890, 화합물

실험 절차

4-(8-Amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl)-N-ethylpiperidine-1-carboxamide was synthesized using the same procedure as 1-{4-[8-amino-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-3-yl]piperidin-1-yl}ethanone except ethylisocyanate was used instead of acetic anhydride; yellow powder; MS (ES+): m/z 492.10 (70) [MH+], 493.11 (45) [MH+2], 211.41 (100) [MH−280]; HPLC: tR=2.08 min (polar-5 min/openlynx).

후처리

  1. customHPLC: tR=2.08 min (polar-5 min/openlynx)

출처 및 근거

ORD 기록
ord-22e12213dc9841ca91ceafc8a995d713
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101613B2

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