Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
3-(Trifluoromethyl)piperidine → 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 3-(Trifluoromethyl)piperidine | HCID 2760776 | — |
| 반응물 | 4-(2-Butynyloxy)-6-fluoropyrimidine | HCID 59661969 | — |
| 용매 | Toluene | HCID 1140 | — |
| 생성물 | 4-(2-Butynyloxy)-6-(3-trifluoromethylpiperidino)pyrimidine | HCID 57672951 | — |
반응 단계
0.2 g of 4-(2-butynyloxy)-6-fluoropyrimidine and 0.15 g of 3-trifluoromethylpiperidine are added to 1 ml of toluene, then the mixture is stirred at room temperature for 30 minutes. Then the reaction mixture is subjected to silica gel column chromatography to obtain 4-(2-butynyloxy)-6-(3-trifluoromethylpyperidino)pyrimidine (referred as the present compound (10) hereinafter).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08101753B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-396961e1920d455cb9aea8f8df2fdd63 |
| 출처 메모 | uspto-grants-2012_01 |