Methanol → Dimethyl 4-hydroxyisophthalate

HRID 423264

반응식

HRID 423264 반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[CH:4][C:3]=1[C:11]([OH:13])=[O:12].S(=O)(=O)(O)O.[C:19](=O)(O)[O-].[Na+].[CH3:24][OH:25]>O>[CH3:24][O:25][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([OH:1])=[C:3]([C:11]([O:13][CH3:19])=[O:12])[CH:4]=1

참가 물질

6

반응물 4

HCID 887MethanolHCID 1118Sulfuric AcidHCID 124904-Hydroxyisophthalic acidHCID 516892Sodium Bicarbonate

생성물 1

HCID 80087Dimethyl 4-hydroxyisophthalate

시약·촉매·용매 1

HCID 962Water용매

실험 절차

To a solution of 4-hydroxyisophthalic acid (16.0 g) in methanol (150 mL) was added conc. sulfuric acid (5 mL), and the mixture was heated for 22 hours under reflux. Then, the reaction solution was allowed to stand for cooling down to room temperature, diluted with water (150 mL), and added with sodium bicarbonate (15 g). The resulting precipitate was filtered, washed successively with water/methanol (1:1, v/v) (150 mL) and water, and dried to give the title compound (17.45 g).

후처리

  1. temperaturethe mixture was heated for 22 hours
  2. temperatureunder reflux
  3. filtrationThe resulting precipitate was filtered
  4. washwashed successively with water/methanol (1:1
  5. dry with materialv/v) (150 mL) and water, and dried

출처 및 근거

ORD 기록
ord-30654b4550c94ee293b82d838b3f59c9
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101774B2

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