Ethanol → Ethyl 3-bromo-2,2-dimethylpropanoate

HRID 423301노트

반응식

HRID 423301 반응식
[Br:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4]([OH:6])=[O:5].OS(O)(=O)=O.[CH3:14][CH2:15]O>>[Br:1][CH2:2][C:3]([CH3:8])([CH3:7])[C:4]([O:6][CH2:14][CH3:15])=[O:5]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 2719323-Bromo-2,2-dimethylpropanoic acid

생성물 1

HCID 12373576Ethyl 3-bromo-2,2-dimethylpropanoate

실험 절차

3-Bromo-2,2-dimethylpropanoic acid (200 mg) was dissolved in EtOH (5 ml) and treated with concentrated H2SO4 (0.4 ml). This mixture was heated at reflux overnight then evaporated. The residue was extracted from H2O with EtOAc (×2) and the combined organic solutions dried and evaporated to give the title compound (316 mg) as a clear oil. δH (CDCl3, 400 MHz) 1.20 (3H, t), 1.32 (6H, s), 3.51 (2H, s), 4.18 (2H, q).

후처리

  1. temperatureThis mixture was heated
  2. temperatureat reflux overnight
  3. customthen evaporated
  4. extractionThe residue was extracted from H2O with EtOAc (×2)
  5. customthe combined organic solutions dried
  6. customevaporated

출처 및 근거

ORD 기록
ord-a01ad34764be4e8ca509ba0e5feb857c
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101775B2

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