홈MCP워크벤치Skills
홈워크벤치알림마이페이지
llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
  1. 홈
  2. /반응

N-methyl-2-pyrrolidone → 5-Aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide

HRID 42342
노트
인쇄 미리보기

반응식

HRID 42342 반응식
NCC1C=CC(S([NH:12][C:13]([CH3:16])([CH3:15])[CH3:14])(=O)=O)=CC=1C.Cl[C:19]1[CH:20]=[CH:21][C:22]([F:29])=[C:23]([S:25](Cl)(=[O:27])=[O:26])[CH:24]=1.[CH3:30][N:31]1C(=O)CCC1>C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.C1C=CC(P(C2C=CC=CC=2)[C-]2C=CC=C2)=CC=1.Cl[Pd]Cl.[Fe+2]>[NH2:31][CH2:30][C:19]1[CH:20]=[CH:21][C:22]([F:29])=[C:23]([S:25]([NH:12][C:13]([CH3:16])([CH3:15])[CH3:14])(=[O:27])=[O:26])[CH:24]=1
참가 물질반응 조건실험 절차출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 13387N-methyl-2-pyrrolidoneHCID 27782735-Chloro-2-fluorobenzenesulfonyl chlorideHCID 582753444-Aminomethyl-N-tert-butyl-3-methyl-benzenesulfonamide

생성물 1

HCID 287163695-Aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide

시약·촉매·용매 1

HCID 44119782Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+)
촉매

반응 조건

온도
120 °C

실험 절차

5-Aminomethyl-N-tert-butyl-2-fluoro-benzenesulfonamide was synthesized in a manner analogous to 4-Aminomethyl-N-tert-butyl-3-methyl-benzenesulfonamide in Example 4, using 5-chloro-2-fluorobenzene-1-sulfonyl chloride in place of 4-bromo-3-methylbenzene-1-sulfonyl chloride. In the second step NMP was used as the solvent, Pd(dppf)Cl2 alone was used as catalyst and the reaction mixture was stirred at 120° C. for 15 hours.

출처 및 근거

ORD 기록
ord-d091dfa4a41044699fc0cce15c88e16a
출처 데이터셋
uspto-grants-2013_09
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08536187B2

반응 노트

불러오는 중…

이 페이지에서참가 물질반응 조건실험 절차출처 및 근거반응 노트