참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Nitric Acid | HCID 944 | — |
| 반응물 | N-(2,5-difluorophenyl)benzenesulfonamide | HCID 8500589 | — |
| 반응물 | Sodium Nitrite | HCID 23668193 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | 2,5-difluoro-4-nitro-N-benzenesulphonylaniline | HCID 20151986 | — |
반응 단계
To 310 ml of acetic acid diluted with 160 ml of water are added: 1.5 g of sodium nitrite, 0.16 mole (42 g) of 2,5-difluoro-N-benzenesulphonylaniline prepared in the previous stage and 0.94 mole (39 ml) of nitric acid (d=1.52). The reaction mixture is heated to 96° C. for 1 hour. After cooling it is poured onto 1 kg of ice and water. The expected product precipitates. After being filtered off and washed to neutrality it is recrystallized from 250 ml of acetic acid; it melts at 176° C.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US04725283 |
|---|
| 출처 데이터셋 | uspto-grants-1988_02 |
|---|
| ORD ID | ord-6690a163904649839ee51f83c59f74e3 |
|---|
| 출처 메모 | uspto-grants-1988_02 |
|---|
