Cyclopropanol → (R)-4-{1-[6-(4-Fluoro-phenyl)-4-cyclopropoxy-pyrido[3,2-d]pyrimidin-2-ylamino]-ethyl}-benzenesulfonamide
반응식
N1([O:10][C:11]2[C:12]3[N:33]=[C:32]([C:34]4[CH:39]=[CH:38][C:37]([F:40])=[CH:36][CH:35]=4)[CH:31]=[CH:30][C:13]=3[N:14]=[C:15]([NH:17][C@@H:18]([C:20]3[CH:25]=[CH:24][C:23]([S:26]([NH2:29])(=[O:28])=[O:27])=[CH:22][CH:21]=3)[CH3:19])[N:16]=2)C2C=CC=CC=2N=N1.[CH:41]1(O)[CH2:43][CH2:42]1>COCCOC>[F:40][C:37]1[CH:38]=[CH:39][C:34]([C:32]2[CH:31]=[CH:30][C:13]3[N:14]=[C:15]([NH:17][C@@H:18]([C:20]4[CH:21]=[CH:22][C:23]([S:26]([NH2:29])(=[O:28])=[O:27])=[CH:24][CH:25]=4)[CH3:19])[N:16]=[C:11]([O:10][CH:41]4[CH2:43][CH2:42]4)[C:12]=3[N:33]=2)=[CH:35][CH:36]=1참가 물질
4
실험 절차
A mixture of (R)-4-(1-(4-(1H-benzo[d][1, 2, 3]triazol-1-yloxy)-6-(4-fluorophenyl)pyrido[3,2-d]pyrimidin-2-ylamino)ethyl)benzenesulfonamide (80 mg), cyclopropanol (0.1 ml) and CsCO3 (94 mg) in DME (3 ml) was stirred at room temperature over the weekend. The reaction mixture was concentrated and purified by reverse phase HPLC (eluting with ACN/H2O+0.1% TFA) to give the title compound, which was characterized by its NMR and mass spectrum as follows: 1H NMR (CD3OD): d 0.83-1.04 (m, 4H), 1.66-1.70 (m, 3H). 4.50-4.58 (m, 1H), 5.40-5.49 (m, 1H), 7.19 (t, 2H), 7.61-7.88 (m, 4H), 7.99-8.02 (m, 1H), 8.08-8.13 (m, 2H), 8.30 (s, 1H); MS (m/z): 480.3 ([M+H]+, 100).