Sodium Sulfite → Sodium 5-bromo-2-methoxybenzenesulfinate

HRID 42355노트

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HRID 42355 반응식
[O-]S([O-])=O.[Na+:5].[Na+].C([O-])(O)=O.[Na+].[Br:12][C:13]1[CH:14]=[CH:15][C:16]([O:23][CH3:24])=[C:17]([S:19](Cl)(=[O:21])=[O:20])[CH:18]=1>O.O1CCOCC1>[Br:12][C:13]1[CH:14]=[CH:15][C:16]([O:23][CH3:24])=[C:17]([S:19]([O-:21])=[O:20])[CH:18]=1.[Na+:5]

참가 물질

6

반응물 3

HCID 24437Sodium SulfiteHCID 516892Sodium BicarbonateHCID 5200205-Bromo-2-methoxybenzene-1-sulfonyl chloride

생성물 1

HCID 67162120Sodium 5-bromo-2-methoxybenzenesulfinate

시약·촉매·용매 2

HCID 962Water용매HCID 312751,4-Dioxane용매

반응 조건

온도
70 °C

실험 절차

To a solution of Na2SO3 (1.42 g) and NaHCO3 (0.948 g) in H2O (17 ml) at 70° C. was added a solution of 5-bromo-2-methoxybenzene-1-sulfonyl chloride (2 g) in dioxane (17 ml) dropwise. The reaction mixture was stirred at 70° C. for 80 minutes and cooled to room temperature. The solvent was removed under vacuum to yield sodium 5-bromo-2-methoxybenzenesulfinate as white solid. The solid was placed under high vacuum overnight and used without further purification.

후처리

  1. temperaturecooled to room temperature
  2. customThe solvent was removed under vacuum

출처 및 근거

ORD 기록
ord-af953d32c592450796c85f7988a72c99
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536187B2

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