Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Sodium Carbonate → 4'-(Methylsulfonyl)-2,4-biphenyldiol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Sodium Carbonate | HCID 10340 | — |
| 반응물 | 4-Bromoresorcinol | HCID 81105 | — |
| 반응물 | 4-(Methanesulfonyl)phenylboronic acid | HCID 2734364 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | 1,2-Dimethoxyethane | HCID 8071 | — |
| 생성물 | 4'-(Methylsulfonyl)-2,4-biphenyldiol | HCID 66673087 | 36% |
반응 단계
4′-(Methylsulfonyl)-2,4-biphenyldiol (500 mg, 36%) was prepared as a clear oil from [4-(methylsulfonyl)phenyl]boronic acid (1.06 g, 5.29 mmol), 4-bromo-1,3-benzenediol (1 g, 5.29 mmol), Pd(PPh3)2Cl2 (100 mg, 0.14 mmol), 2M Na2CO3 (5 mL) and DME (5 mL) in a manner similar to Example 21, Step 3. 1H NMR (400 MHz, DMSO-d6) δ 9.68 (s, 1H), 9.52 (s, 1H), 7.88-7.80 (m, 2H), 7.75-7.69 (m, 2H), 7.13 (d, 1H, J=8.4 Hz), 6.41 (d, 1H, J=2.2 Hz), 6.32 (dd, 1H, Ja=8.4 Hz, Jb=2.4 Hz), 3.31 (s, 3H); LRMS (ESI), m/z 263 (M−H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08101634B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-cd0c7454f7794b1abc45067d6739a21e |
| 출처 메모 | uspto-grants-2012_01 |