Ammonium Chloride → HCID 178462231, 화합물

HRID 423708노트

반응식

HRID 423708 반응식
[OH:1][C@@H:2]([CH:4]1[CH2:9][CH2:8][N:7]([C:10]#[N:11])[CH2:6][CH2:5]1)[CH3:3].[Cl-].[NH4+].[N-:14]=[N+:15]=[N-:16].[Na+]>CN(C=O)C>[NH:14]1[C:10]([N:7]2[CH2:6][CH2:5][CH:4]([C@H:2]([OH:1])[CH3:3])[CH2:9][CH2:8]2)=[N:11][N:16]=[N:15]1

참가 물질

5

반응물 3

HCID 25517Ammonium ChlorideHCID 33557Sodium AzideHCID 866387534-[(1R)-1-hydroxyethyl]-1-piperidinecarbonitrile

생성물 1

HCID 178462231HCID 178462231, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

A solution of 4-[(1R)-1-hydroxyethyl]-1-piperidinecarbonitrile (200 mg, 1.30 mmol) in DMF (5 mL) was treated with ammonium chloride (104 mg, 1.95 mmol) and sodium azide (126 mg, 1.95 mmol) at room temperature. The mixture was heated at 100° C. for 14 h. After allowing the mixture to cool, the solid was removed by filtration and washed with DMF. The filtrate was concentrated to give (1R)-1-[1-(1H-tetrazol-5-yl)-4-piperidinyl]ethanol, which was used without further purification.

후처리

  1. temperatureto cool
  2. customthe solid was removed by filtration
  3. washwashed with DMF
  4. concentrationThe filtrate was concentrated

출처 및 근거

ORD 기록
ord-f279832174a74669bc6b866c75fe8482
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08101634B2

반응 노트

불러오는 중…