참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Chloride | HCID 312 | — |
| 반응물 | Tetrahydrofuran | HCID 8028 | — |
| 반응물 | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| 반응물 | tert-Butyl (6-chloro-2-formylpyridin-3-yl)carbamate | HCID 58216578 | — |
| 용매 | Chloroform | HCID 6212 | — |
| 생성물 | 6-Chloro-3-phenyl-1,5-naphthyridin-2(1H)-one | HCID 66524919 | — |
반응 단계
A mixture of tert-butyl (6-chloro-2-formylpyridin-3-yl)carbamate (1-4) (5 g, 19.5 mmol), phenylacethyl chloride (3.3 g, 21.4 mmol), and DBU (9.8 g, 39 mmol) in THF (215 mL) was stirred at room temperature for 2 days and at 100° C. for overnight. The mixture was diluted with CHCl3, washed with water and brine, dried (MgSO4), filtered, and the solvent was removed under reduced pressure. To the residue was added CHCl3, and the resulting solid was collected by filtration to give 6-chloro-3-phenyl-1,5-naphthyridin-2(1H)-one (7-1) as colorless solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08536193B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-9e8b644fdd414a4ab4ff50a1954391a0 |
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| 출처 메모 | uspto-grants-2013_09 |
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