참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Difluoroacetic acid | HCID 9788 | — |
| 반응물 | Ethyl difluoroacetate | HCID 9961 | — |
| 반응물 | 6-Hydrazinyl-3-phenyl-1,5-naphthyridin-2(1H)-one | HCID 67069008 | — |
| 용매 | 1,3-Dimethyl-2-imidazolidinone | HCID 6661 | — |
| 생성물 | 1-(Difluoromethyl)-8-phenyl-[1,2,4]triazolo[4,3-a][1,5]naphthyridin-7(6H)-one | HCID 67094079 | — |
반응 단계
A mixture of 6-hydrazino-3-phenyl-1,5-naphthyridin-2(1H)-one (7-2) (21 g, 83 mmol), ethyl difluoroacetate (31 g, 250 mmol), and difluoroacetic acid (200 mg, 2.08 mmol) in DMI (100 mL) was heated under microwave irradiation at 200° C. for 1 h. To the cooled mixture was added water, and the resulting solid was collected by filtration to give 1-(difluoromethyl)-8-phenyl[1,2,4]triazolo[4,3-a]-1,5-naphthyridin-7(6H)-one (10-1) as pale yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08536193B2 |
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| 출처 데이터셋 | uspto-grants-2013_09 |
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| ORD ID | ord-bb3372ca47a9425ba89b4ac18a1052b0 |
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| 출처 메모 | uspto-grants-2013_09 |
|---|
