Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triphenylphosphine → N-[3-(3-methyl-but-3-enyloxy)-phenyl]-acetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | 3-Hydroxyacetanilide | HCID 12124 | — |
| 반응물 | 3-Methyl-3-buten-1-ol | HCID 12988 | — |
| 반응물 | Diethyl azodicarboxylate | HCID 5462977 | — |
| 반응물 | Acetic acid 3-formylamino-phenyl ester | HCID 57470213 | — |
| 용매 | Benzene | HCID 241 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | N-[3-(3-methyl-but-3-enyloxy)-phenyl]-acetamide | HCID 57567384 | 52% |
반응 단계
A suspension of the mixture of N-(3-hydroxy-phenyl)-acetamide and acetic acid 3-formylamino-phenyl ester (18.12 g, 0.12 mol), 3-methyl-but-3-en-1-ol (8.6 g, 0.1 mol), DEAD (87 g, 0.2 mol) and Ph3P (31.44 g, 0.12 mol) in benzene (250 mL) was heated at reflux overnight and then cooled to room temperature. The reaction mixture was poured into water and the organic layer was separated. The aqueous phase was extracted with EtOAc (300×3 mL). The combined organic layers were washed with brine, dried over anhydrous Na2SO4 and concentrated. The residue was purified by column chromatography to give N-[3-(3-methyl-but-3-enyloxy)-phenyl]-acetamide (11 g, 52%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08101767B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-021becc2882647d9a3eeac70fe12e297 |
| 출처 메모 | uspto-grants-2012_01 |