Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydroxylamine → 7-nitro-3,4-dihydro-2H-naphthalen-1-one oxime
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydroxylamine | HCID 787 | — |
| 반응물 | 7-Nitro-1-tetralone | HCID 38445 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | 7-nitro-3,4-dihydro-2H-naphthalen-1-one oxime | HCID 300031 | 88% |
반응 단계
To a solution of 7-nitro-3,4-dihydro-2H-naphthalen-1-one (500 mg, 2.62 mmol) in pyridine (2 mL) was added hydroxylamine solution (1 mL, ˜50% solution in water). The reaction was stirred at room temperature for 1 h, then concentrated and purified by column chromatography (10-50% ethyl acetate-hexanes) to yield 7-nitro-3,4-dihydro-2H -naphthalen-1-one oxime (471 mg, 88%). HPLC ret. time 2.67 min, 10-99% CH3CN, 5 min run; ESI-MS 207.1 m/z (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08101767B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-e128b2be720c4c8db8e3f63bf594f2a2 |
| 출처 메모 | uspto-grants-2012_01 |