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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 423998생성일: 2026년 10월 26일

2,5-Dichlorothiophene-3-sulfonyl chloride → 2,5-Dichloro-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)thiophene-3-sulfonamide

https://huagongshe.com/reaction/423998

반응식

참여 물질

역할이름HCID투입량
반응물2,5-Dichlorothiophene-3-sulfonyl chlorideHCID 2736094—
반응물5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene-1,2-diamineHCID 59386306—
생성물2,5-Dichloro-N-(3,4-difluoro-2-(2-fluoro-4-iodophenylamino)phenyl)thiophene-3-sulfonamideHCID 56953321—

반응 단계

According to the general procedure B, 5,6-difluoro-N1-(2-fluoro-4-iodophenyl)benzene1,2-diamine was reacted with 2,5-dichlorothiophene-3-sulfonyl chloride to obtain the title compound. 1H NMR (300 MHz, CDCl3): δ 7.41 (dd, J=1.5 & 10.5 Hz, 1H), 7.28-7.20 (m, 2H), 7.08 (dd, J=9.0 & 17.4 Hz, 2H), 6.99 (s, 1H), 6.03 (dt, J=2.1, 8.7 & 17.4 Hz, 1H), 5.56 (br s, 1H).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08101799B2
출처 데이터셋uspto-grants-2012_01
ORD IDord-ce9f8b0c4f224fe28e9dc27c57cce7e0
출처 메모uspto-grants-2012_01