참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 2-Methyltetrahydrofuran | HCID 7301 | — |
| 반응물 | 4-Nitrophenyl chloroformate | HCID 82129 | — |
| 반응물 | 1-Phenylethanol, (R)- | HCID 637516 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Carbonic acid 4-nitro-phenyl ester (R)-1-phenyl-ethyl ester | HCID 11108942 | 98.3% |
반응 단계
A mixture of (R)-1-phenyl-ethanol (60.6 g, 0.496 mol), pyridine (42.5 mL, 0.526 mol) and 2-methyl-tetrahydrofuran (600 mL) was cooled to 0° C. and p-nitrophenyl chloroformate (100 g, 0.496 mol) was added over 15 min keeping the internal temperature below 5° C. The reaction mixture was warmed to room temperature and stirred for 2 h. To the reaction mixture was added 1.0 M HCl in water (300 mL). Layers were separated. The organic layer was washed with 1N HCl (300 mL) and brine (300 mL), filtered, concentrated to dryness by rotary evaporation, and dried under vacuum to give the title compound (140 g) as a clear yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08101791B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_01 |
|---|
| ORD ID | ord-e9d41a3fd0764904b280ca3a75b9a963 |
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| 출처 메모 | uspto-grants-2012_01 |
|---|
