Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1,2-Dichloroethane → HCID 67467953, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1,2-Dichloroethane | HCID 11 | — |
| 반응물 | 4-Methylmorpholine | HCID 7972 | — |
| 반응물 | HOAt | HCID 181649 | — |
| 반응물 | 3-(Aminomethyl)-6-methyl-4-propylpyridin-2(1H)-oneacetate | HCID 67124140 | — |
| 반응물 | 1-(1-Methylethyl)-7-(methyloxy)-1H-indole-4-carboxylic acid | HCID 67468682 | — |
| 용매 | Dimethyl Sulfoxide | HCID 679 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | HCID 67467953 | HCID 67467953 | 60.8% |
반응 단계
Added 1-(1-methylethyl)-7-(methyloxy)-1H-indole-4-carboxylic acid (160 mg, 0.686 mmol), 3-(aminomethyl)-6-methyl-4-propyl-2(1H)-pyridinone (186 mg, 0.857 mmol), 1-hydroxy-7-azabenzotriazole (187 mg, 1.372 mmol), EDC (263 mg, 1.372 mmol) and N-methylmorpholine (0.302 mL, 2.74 mmol) to DMSO (10 mL) and stirred mixture at RT for 16 h. Added 25 ml of water and stirred for 10 minutes. Filtered off solids and dried in vacuo. The solids were purified by column chromatography (Biotage; 0% to 15% gradient MeOH:DCM; 10 g-HP-silica gel column) to give 165 mg of 1-(1-methylethyl)-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinyl)methyl]-7-(methyloxy)-1H-indole-4-carboxamide.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08536179B2 |
| 출처 데이터셋 | uspto-grants-2013_09 |
| ORD ID | ord-2afcf149aed4450c94b1257efecfe8ae |
| 출처 메모 | uspto-grants-2013_09 |