6-Methyl-2-oxo-4-propyl-1,2-dihydropyridine-3-carbonitrile → 3-(Aminomethyl)-6-methyl-4-propylpyridin-2(1H)-oneacetate

HRID 42460노트

반응식

HRID 42460 반응식
[NH2:1][CH2:2][C:3]1[C:4](=[O:16])[NH:5][C:6]([CH3:15])=[CH:7][C:8]=1[CH:9]1CCC[CH2:11][CH2:10]1.CC1NC(=O)C(C#N)=C(CCC)C=1>>[NH2:1][CH2:2][C:3]1[C:4](=[O:16])[NH:5][C:6]([CH3:15])=[CH:7][C:8]=1[CH2:9][CH2:10][CH3:11]

참가 물질

3

반응물 2

HCID 156418016-Methyl-2-oxo-4-propyl-1,2-dihydropyridine-3-carbonitrileHCID 671243593-(aminomethyl)-4-cyclohexyl-6-methyl-2(1H)-pyridinone2회

생성물 1

HCID 671241403-(Aminomethyl)-6-methyl-4-propylpyridin-2(1H)-oneacetate

실험 절차

The title compound was prepared in the same manner as described for 3-(aminomethyl)-4-cyclohexyl-6-methyl-2(1H)-pyridinone (Intermediate 3) using 6-methyl-2-oxo-4-propyl-1,2-dihydro-3-pyridinecarbonitrile (2 g, 11.2 mmol). Obtained: 1.2 g (60%). LCMS E-S (M+H)=181.1. 1H NMR (400 MHz, DMSO-d6) δ ppm 7.85-7.95 (br s, 3H), 5.99 (s, 1H), 3.80-3.85 (m, 2H), 2.42 (t, 2H), 2.14 (s, 3H), 1.43-1.49 (m, 2H), 0.86 (t, 3H).

후처리

  1. customObtained

출처 및 근거

ORD 기록
ord-cd84f7194ee642bf95a8a6e7e538d542
출처 데이터셋
uspto-grants-2013_09
특허 번호
US08536179B2

반응 노트

불러오는 중…