Benzoyl Peroxide → 3-(Bromomethyl)isothiazolo[5,4-b]pyridine
반응식
[Br:1]NC(=O)CCC(N)=O.[CH3:10][C:11]1[C:19]2[C:14](=[N:15][CH:16]=[CH:17][CH:18]=2)[S:13][N:12]=1.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Br:1][CH2:10][C:11]1[C:19]2[C:14](=[N:15][CH:16]=[CH:17][CH:18]=2)[S:13][N:12]=1참가 물질
5
실험 절차
N-Bromosuccinamide (10.7 mmol) was added to a solution of 3-methylisothiazolo[5,4-b]pyridine (10.0 mmol) in carbontetrachloride (20 mL). Benzoyl peroxide (0.82 mmol) was added and the reaction mixture was heated at reflux for 48 h. The reaction mixture was filtered through Celite (ethyl acetate) and the eluent was concentrated to provide crude 3-(bromomethyl)isothiazolo[5,4-b]pyridine as a yellow solid.
후처리
- temperaturethe reaction mixture was heated
- temperatureat reflux for 48 h
- filtrationThe reaction mixture was filtered through Celite (ethyl acetate)
- concentrationthe eluent was concentrated
출처 및 근거
- ORD 기록
- ord-b478c96bbd39448c9af2860e121b0708
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08106066B2
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