benzyl (2R)-2-(dimethylcarbamoyl)pyrrolidine-1-carboxylate → (2R)-N,N-dimethylpyrrolidine-2-carboxamide
반응식
C(OC([N:11]1[CH2:20][CH2:19][CH2:18][C@@H:12]1[C:13]([N:15]([CH3:17])[CH3:16])=[O:14])=O)C1C=CC=CC=1>[OH-].[Pd+2].[OH-].CO>[CH3:16][N:15]([CH3:17])[C:13](=[O:14])[C@H:12]1[CH2:18][CH2:19][CH2:20][NH:11]1참가 물질
4
실험 절차
To the subtitle compound of step i) (4.45 g) was added palladium hydroxide (0.20 g) and methanol (50 ml). The mixture was stirred under a hydrogen atmosphere (4 bar) at room temperature for 3 h before the catalyst was filtered through celite and the solvent was evaporated to afford the subtitle compound as a solid. Yield: 2.25 g.
후처리
- filtrationwas filtered through celite
- customthe solvent was evaporated
출처 및 근거
- ORD 기록
- ord-9eb82b4e056e41f5b7f2a25294e518ca
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08106063B2
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