Sulfamide → 1-(Aminosulfonyl)-N,N-dimethyl-D-prolinamide
반응식
[CH3:1][N:2]([CH3:10])[C:3](=[O:9])[C@H:4]1[CH2:8][CH2:7][CH2:6][NH:5]1.[S:11](N)([NH2:14])(=[O:13])=[O:12]>O1CCOCC1>[NH2:14][S:11]([N:5]1[CH2:6][CH2:7][CH2:8][C@@H:4]1[C:3]([N:2]([CH3:10])[CH3:1])=[O:9])(=[O:13])=[O:12]참가 물질
4
실험 절차
To a solution of the subtitle compound of step ii) (2.20 g) in dioxane (25 ml) was added sulfamide (7.20 g) and the mixture heated at reflux for 45 h. The reaction mixture was cooled and adsorbed on to silica gel and then purified by column chromatography (5% methanol/EtOAc) to afford the subtitle compound as an oil. Yield: 1.6 g.
후처리
- temperaturethe mixture heated
- temperatureat reflux for 45 h
- temperatureThe reaction mixture was cooled
- custompurified by column chromatography (5% methanol/EtOAc)
출처 및 근거
- ORD 기록
- ord-6e5f3436834e445696a07647c4fd9080
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08106063B2
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