Oxetan-2-ylmethyl 4-methylbenzenesulfonate → 2-(Oxetan-2-ylmethyl)isoindoline-1,3-dione

HRID 424762노트

반응식

HRID 424762 반응식
S(O[CH2:12][CH:13]1[CH2:16][CH2:15][O:14]1)(C1C=CC(C)=CC=1)(=O)=O.[C:17]1(=[O:27])[NH:21][C:20](=[O:22])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]12.[K]>CN(C=O)C>[C:17]1(=[O:27])[N:21]([CH2:12][CH:13]2[CH2:16][CH2:15][O:14]2)[C:20](=[O:22])[C:19]2=[CH:23][CH:24]=[CH:25][CH:26]=[C:18]12

참가 물질

4

반응물 2

HCID 13927594Oxetan-2-ylmethyl 4-methylbenzenesulfonateHCID 24194345Phthalimide potassium salt

생성물 1

HCID 598409352-(Oxetan-2-ylmethyl)isoindoline-1,3-dione

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
120 °C

실험 절차

A solution of 2-(tosyloxymethyl)oxetane (27 g, 111.4 mmol) (prepared according to A. O. Fitton et al., Synthesis 1987, (12), 1140-2) and potassium phtalimide (20.64 g, 111.4 mmol) in DMF (200 ml) is stirred at a temperature of 120° C. for 18 hours, then evaporated in vacuo. The residue is taken up in ethyl acetate, the organic layer washed with water and brine, dried (Na2SO4), filtered, and evaporated to dryness. The crude solid product (19.8 g, 82%) is used in the next step without further purification.

후처리

  1. customevaporated in vacuo
  2. washthe organic layer washed with water and brine
  3. dry with materialdried (Na2SO4)
  4. filtrationfiltered
  5. customevaporated to dryness
  6. customThe crude solid product (19.8 g, 82%) is used in the next step without further purification

출처 및 근거

ORD 기록
ord-c72bef309ca84da2be1ea59c7b8f74f8
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106075B2

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