2-Phenyl-5-trifluoromethyl-2H-pyrazol-3-ol → alpha-hydroxy-2,5-dihydro-5-oxo-1-phenyl-alpha-trifluoromethyl-3-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester

참여 물질

반응 조건

반응 단계

To a chloroform solution (5 ml) of 1-phenyl-3-trifluoromethyl-5-pyrazolone (114 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a colorless solid (172 mg).

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