Methyl 3,3,3-trifluoro-2-oxopropanoate → 1-(4-chlorophenyl)-2,5-dihydro-alpha-hydroxy-3-methyl-5-oxo-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester

참여 물질

역할	이름	HCID	투입량
반응물	Methyl 3,3,3-trifluoro-2-oxopropanoate	HCID 2734931	—
반응물	2-(4-Chlorophenyl)-5-methyl-1H-pyrazol-3(2H)-one	HCID 3442874	—
용매	Chloroform	HCID 6212	—
생성물	1-(4-chlorophenyl)-2,5-dihydro-alpha-hydroxy-3-methyl-5-oxo-alpha-trifluoromethyl-1H-pyrazole-4-acetic acid methyl ester	HCID 44139819	—

반응 조건

온도	80 °C

반응 단계

To a chloroform solution (5 ml) of 1-(4-chlorophenyl)-3-methyl-5-pyrazolone (104 mg, 0.5 mmol), methyl trifluoropyruvate (78 mg, 0.5 mmol) was added at room temperature and the mixture was stirred at 80° C. for 2 hours. After removing the solvent under reduced pressure, the title compound was obtained as a colorless solid (182 mg).

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US08106086B2
출처 데이터셋	uspto-grants-2012_01
ORD ID	ord-e79a7b146dc941908744a9ae7843889e
출처 메모	uspto-grants-2012_01