Triethylamine → Methanesulfonic acid 2-(5-bromo-benzothiazol-2-yl)-ethyl ester

HRID 424937

반응식

HRID 424937 반응식
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([CH2:10][CH2:11][OH:12])=[N:7][C:6]=2[CH:13]=1.CCN(CC)CC.[CH3:21][S:22](Cl)(=[O:24])=[O:23]>C(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[S:9][C:8]([CH2:10][CH2:11][O:12][S:22]([CH3:21])(=[O:24])=[O:23])=[N:7][C:6]=2[CH:13]=1

참가 물질

5

반응물 3

HCID 8471TriethylamineHCID 31297Methanesulfonyl chlorideHCID 219800605-Bromo-2-benzothiazoleethanol

생성물 1

HCID 21041502Methanesulfonic acid 2-(5-bromo-benzothiazol-2-yl)-ethyl ester

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a mixture of 2-(5-bromo-benzothiazol-2-yl)-ethanol (0.94 g, 3.6 mmol) in 10 mL CH2Cl2, Et3N (0.99 g, 9.8 mmol), was added methanesulfonyl chloride (0.46 g, 4.0 mmol) dropwise at room temperature. The reaction was worked up by concentrating under vacuum and then used in the next step, Example 1C.

후처리

  1. concentrationby concentrating under vacuum

출처 및 근거

ORD 기록
ord-e7dcb545557e41e8b09838c68bacf468
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106088B2

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