erythro-N-Boc-D-phenylalanine epoxide → [(1R,2S)-1-Benzyl-2-hydroxy-3-[1,2,3]triazol-2-yl-propyl]-carbamic acid tert-butyl ester

HRID 424984

반응식

HRID 424984 반응식
[C:1]([O:5][C:6](=[O:19])[NH:7][C@@H:8]([C@@H:16]1[CH2:18][O:17]1)[CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)([CH3:4])([CH3:3])[CH3:2].[NH:20]1[CH:24]=[CH:23][N:22]=[N:21]1>>[C:1]([O:5][C:6](=[O:19])[NH:7][C@H:8]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[C@@H:16]([OH:17])[CH2:18][N:21]1[N:22]=[CH:23][CH:24]=[N:20]1)([CH3:4])([CH3:3])[CH3:2]

참가 물질

3

반응물 2

HCID 11357515erythro-N-Boc-D-phenylalanine epoxideHCID 178418936HCID 178418936, 화합물

생성물 1

HCID 66703577[(1R,2S)-1-Benzyl-2-hydroxy-3-[1,2,3]triazol-2-yl-propyl]-carbamic acid tert-butyl ester

실험 절차

Using general procedure 4 and purification method E with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.15 g, 0.57 mmol) and 1,2,3-triazole (0.037 mL, 0.63 mmol) gives the title compound.

출처 및 근거

ORD 기록
ord-3e64b570bd2d4dad8cb6ce7b6456555e
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106090B2

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