Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
L-Prolinamide → [(1R,2S)-1-Benzyl-3-([2S]-2-carbamoyl-pyrrolidin-1-yl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | L-Prolinamide | HCID 111306 | — |
| 반응물 | erythro-N-Boc-D-phenylalanine epoxide | HCID 11357515 | — |
| 생성물 | [(1R,2S)-1-Benzyl-3-([2S]-2-carbamoyl-pyrrolidin-1-yl)-2-hydroxy-propyl]-carbamic acid tert-butyl ester | HCID 66703646 | — |
반응 단계
Using general procedure 1 and purification method D with [(1R)-1-{(2R)-oxiran-2-yl}-2-phenyl-ethyl]carbamic acid tert-butylester (0.10 g, 0.38 mmol) and (S)-proline amide (0.114 g, 0.57 mmol) gives the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08106090B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-c1aac20363f64239b064bf073c992b70 |
| 출처 메모 | uspto-grants-2012_01 |