Sulfamic Acid → 2-Methoxy-5-methylsulfanilic acid

HRID 4252

반응식

HRID 4252 반응식
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([C:7]([CH3:10])=[CH:8][CH:9]=1)[NH2:6].[S:11](=[O:15])(=[O:14])([OH:13])N>C(#N)C>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([NH2:6])[C:7]([CH3:10])=[CH:8][C:9]=1[S:11]([OH:15])(=[O:14])=[O:13]

참가 물질

4

반응물 2

HCID 5987Sulfamic AcidHCID 995005-Methoxy-o-toluidine

생성물 1

HCID 201521062-Methoxy-5-methylsulfanilic acid

시약·촉매·용매 1

HCID 6342Acetonitrile용매

실험 절차

23.1 g of 3-methoxy-6-methylaniline and 16.4 g of sulfamic acid were put into a 100 ml egg-plant type flask and the mixture was heated to temperature of from 150° to 160° C. and maintained thereat for 2 hours. Acetonitrile was added to the reaction mixture and the crystals thus deposited were collected. The crystals were dissolved in an aqueous solution of sodium hydroxide, the solution was filtered and acidified with hydrochloric acid, and the crystals thus deposited were collected by filtration.

후처리

  1. temperaturethe mixture was heated to temperature of from 150° to 160° C.
  2. temperaturemaintained
  3. customthe crystals thus deposited were collected
  4. dissolutionThe crystals were dissolved in an aqueous solution of sodium hydroxide
  5. filtrationthe solution was filtered
  6. filtrationthe crystals thus deposited were collected by filtration

출처 및 근거

ORD 기록
ord-10a5e567c3634c778989865c564fb6c3
출처 데이터셋
uspto-grants-1988_02
특허 번호
US04725531

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