참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Acetic Acid | HCID 176 | — |
| 반응물 | Borane | HCID 6331 | — |
| 반응물 | 3-Methylpyridine | HCID 7970 | — |
| 반응물 | 4-Ethylpyridine | HCID 10822 | — |
| 반응물 | 3-Ethylpyridine | HCID 10823 | — |
| 반응물 | 2-Propylpyridine | HCID 69320 | — |
| 반응물 | Borane;pyridine | HCID 2723995 | — |
| 용매 | Pyridine | HCID 1049 | — |
| 생성물 | Borane;2-methylpyridine | HCID 16217944 | — |
| 생성물 | HCID 178419164 | HCID 178419164 | — |
| 생성물 | HCID 178419168 | HCID 178419168 | — |
| 생성물 | HCID 178419174 | HCID 178419174 | — |
반응 단계
Pyridine forms an amine borane that is not moisture sensitive and very useful for reductive aminations and reductions in protic media. Pyridine borane is commercially available and often used in acetic acid to increase the reactivity of the borane. Unfortunately, it is thermally unstable and must be kept at temperatures less than 54° C. to avoid decomposition via hydroboration/polymerization processes. Its shelf-life at ambient temperature is only 6 months, Borane complexes of pyridine, 2-n-propylpyridine, 3-methylpyridine, 3-ethylpyridine and 4-ethylpyridine are liquids which violently decompose upon distillation (Mooney E. F. et al., J. Inorg. Nucl. Chem 1968, 30, p. 1439). 2-Picoline borane (mp. 50° C.), 2-ethylpyridine borane (mp, 50-51° C.), 2,6-lutidine borane (mp. 106-107° C.) and 2,4,6-collidine borane (mp. 99-100° C.) have been isolated as solids.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08106200B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_01 |
|---|
| ORD ID | ord-4d143ad01d254d1b85140b1240a70419 |
|---|
| 출처 메모 | uspto-grants-2012_01 |
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