Methanol → Methyl 4-bromo-3-fluorobenzeneacetate

HRID 425329노트

반응식

HRID 425329 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]#N)=[CH:4][C:3]=1[F:11].S(=O)(=O)(O)O.[OH2:17].[CH3:18][OH:19]>>[Br:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9]([O:19][CH3:18])=[O:17])=[CH:4][C:3]=1[F:11]

참가 물질

5

반응물 4

HCID 887MethanolHCID 962WaterHCID 1118Sulfuric AcidHCID 116009532-(4-Bromo-3-fluorophenyl)acetonitrile

생성물 1

HCID 71265948Methyl 4-bromo-3-fluorobenzeneacetate

실험 절차

(4-bromo-3-fluorophenyl)acetonitrile (40 g, 0.18 mol) was dissolved in 120 mL methanol, and 65 mL concentrated sulfuric acid were added. After heating at reflux overnight, the reaction mixture was cooled, and poured into 600 mL water, and the product was extracted with CH2Cl2. The combined extracts were washed with 10% sodium carbonate solution, dried, and concentrated to afford methyl (4-bromo-3-fluorophenyl)acetate.

후처리

  1. temperatureAfter heating
  2. temperatureat reflux overnight
  3. temperaturethe reaction mixture was cooled
  4. extractionthe product was extracted with CH2Cl2
  5. washThe combined extracts were washed with 10% sodium carbonate solution
  6. customdried
  7. concentrationconcentrated

출처 및 근거

ORD 기록
ord-c486df2e7ae841448520cfd8662d0b6a
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106070B2

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