Benzyl chloroformate → 2-{[(Benzyloxy)carbonyl]amino}-3-(4-bromophenyl)propanoic acid

HRID 425375노트

반응식

HRID 425375 반응식
Cl[C:2]([O:4][CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1)=[O:3].[Br:12][C:13]1[CH:24]=[CH:23][C:16]([CH2:17][CH:18]([C:20]([OH:22])=[O:21])[NH2:19])=[CH:15][CH:14]=1>C(OCC)(=O)C>[CH2:5]([O:4][C:2]([NH:19][CH:18]([CH2:17][C:16]1[CH:15]=[CH:14][C:13]([Br:12])=[CH:24][CH:23]=1)[C:20]([OH:22])=[O:21])=[O:3])[C:6]1[CH:11]=[CH:10][CH:9]=[CH:8][CH:7]=1

참가 물질

4

반응물 2

HCID 10387Benzyl chloroformateHCID 856814-Bromophenylalanine

생성물 1

HCID 220659152-{[(Benzyloxy)carbonyl]amino}-3-(4-bromophenyl)propanoic acid

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

Benzyl chloroformate (8.65 mL, 61.5 mmol) was added to a refluxing solution of 4-bromo-dl-phenylalanine (15 g, 61.5 mmol) in ethyl acetate (250 mL). After stirring at reflux overnight, the reaction mixture was cooled to ambient temperature, filtered through celite and concentrated in vacuo to afford 2-{[(benzyloxy)carbonyl]amino}-3-(4-bromophenyl)propanoic acid which was used in the subsequent step without further purification.

후처리

  1. temperatureat reflux overnight
  2. filtrationfiltered through celite and
  3. concentrationconcentrated in vacuo

출처 및 근거

ORD 기록
ord-e0dd7a8f33f24837b0f864417f743144
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106070B2

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