2-Trifluoromethylphenol → 3-hydroxy-3-[2-hydroxy-5-(trifluoromethyl)phenyl]-1-pentyl-1,3-dihydro-2H-indol-2-one
반응식
Br[C:2]1[CH:10]=[CH:9][CH:8]=[C:7]2[C:3]=1[C:4](=[O:17])[C:5](=[O:16])[N:6]2[CH2:11][CH2:12][CH2:13][CH2:14][CH3:15].C(N1C2C(=CC=CC=2)C(=O)C1=O)CCCC.O1[C:38]2[CH:39]=[CH:40][C:41]([OH:43])=[CH:42][C:37]=2OC1.[F:44][C:45]([F:54])([F:53])C1C(O)=CC=CC=1>>[OH:17][C:4]1([C:40]2[CH:39]=[C:38]([C:45]([F:54])([F:53])[F:44])[CH:37]=[CH:42][C:41]=2[OH:43])[C:3]2[C:7](=[CH:8][CH:9]=[CH:10][CH:2]=2)[N:6]([CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:5]1=[O:16]참가 물질
5
실험 절차
Following the procedure as described in PREPARATION 1C, and making non-critical variations to replace 4-bromo-1-pentyl-1H-indole-2,3-dione with 1-pentyl-1H-indole-2,3-dione, and 1,3-benzodioxol-5-ol with α,α,α-trifluorocresol, the title compound was obtained (46%): 1H NMR (300 MHz, CDCl3) δ 9.75 (s, 1H), 7.50-7.39 (m, 3H), 7.21 (td, 1H), 7.10-7.02 (m, 2H), 6.96 (d, 1H), 4.26 (s, 1H), 3.82-3.59 (m, 2H), 1.77-1.63 (m, 2H), 1.40-1.27 (m, 4H), 0.88 (t, 3H); MS (ES+) m/z 362 (M−17), 402 (M+23).
출처 및 근거
- ORD 기록
- ord-f27926ba14f44741b08b48b7c609870d
- 출처 데이터셋
- uspto-grants-2012_01
- 특허 번호
- US08106087B2
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