Isatin → 3-(5-bromo-2-hydroxyphenyl)-3-hydroxy-1,3-dihydro-2H-indol-2-one

반응식

C1(CC[N:6]2[C:14]3[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=3)[C:8](=[O:15])[C:7]2=[O:16])CC1.N1C2C(=CC=CC=2)C(=O)C1=O.O1C2C=CC(O)=CC=2OC1.[Br:38][C:39]1[CH:44]=[CH:43][C:42]([OH:45])=[CH:41][CH:40]=1>>[Br:38][C:39]1[CH:40]=[CH:41][C:42]([OH:45])=[C:43]([C:8]2([OH:15])[C:9]3[C:14](=[CH:13][CH:12]=[CH:11][CH:10]=3)[NH:6][C:7]2=[O:16])[CH:44]=1

참가 물질

반응물 4

HCID 7054Isatin

HCID 78084-Bromophenol

HCID 68289Sesamol

HCID 655965701-(2-cyclopropylethyl)-1H-indole-2,3-dione

생성물 1

HCID 120043333-(5-bromo-2-hydroxyphenyl)-3-hydroxy-1,3-dihydro-2H-indol-2-one

실험 절차

Following the procedure as described in PREPARATION 2B, and making non-critical variations to replace 1-(2-cyclopropylethyl)-1H-indole-2,3-dione with isatin, 1,3-benzodioxol-5-ol with 4-bromophenol, the title compound was obtained (71%) as a yellowish solid: MS (ES+) m/z 319.4 (M+1), 321.4 (M+1).