Thionyl Chloride → 6-Chloropyridine-3-carbonyl chloride--hydrogen chloride (1/1)

반응식

[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6](O)=[O:7])=[CH:4][N:3]=1.O=S(Cl)[Cl:13]>>[ClH:1].[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([Cl:13])=[O:7])=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 792226-Chloronicotinic acid

생성물 1

HCID 185485896-Chloropyridine-3-carbonyl chloride--hydrogen chloride (1/1)수율 93%

실험 절차

A solution of 6-chloronicotinic acid (10.00 g, 63.5 mmol) in SOCl2 (37 mL) was heated to reflux for 2 h. The SOCl2 was evaporated to dryness, to afford 12.56 g of the desired product (yield: 93%).

후처리

temperatureto reflux for 2 h
customThe SOCl2 was evaporated to dryness

출처 및 근거

ORD 기록: ord-ca13c246ce1d4aa4be7ba99c5d23ee88
출처 데이터셋: uspto-grants-2013_09
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08536194B2

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