5-Chloro-2-nitrobenzoic acid → 5-Chloro-2-nitrobenzoyl chloride

HRID 425750

반응식

HRID 425750 반응식
[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7](O)=[O:8].S(Cl)([Cl:16])=O>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([N+:11]([O-:13])=[O:12])=[C:6]([CH:10]=1)[C:7]([Cl:16])=[O:8]

참가 물질

3

반응물 2

HCID 172865-Chloro-2-nitrobenzoic acidHCID 24386Thionyl Chloride

생성물 1

HCID 27236855-Chloro-2-nitrobenzoyl chloride수율 98%

실험 절차

100.00 g (0.50 mol) of 5-chloro-2-nitrobenzoic acid were mixed with 72.20 g (0.61 mol) of thionyl chloride and the mixture was heated under reflux for 2 h. The excess thionyl chloride was removed in vacuo. 106.50 g (ca. 98%) of crude 5-chloro-2-nitro-benzoyl chloride were obtained as an oil.

후처리

  1. temperaturethe mixture was heated
  2. temperatureunder reflux for 2 h
  3. customThe excess thionyl chloride was removed in vacuo

출처 및 근거

ORD 기록
ord-ade8d8af17fc4bb89235b739abdf58db
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106213B2

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