Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triacetoxyperiodinane → 4-Chloroquinazoline-6-carbaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triacetoxyperiodinane | HCID 159087 | — |
| 반응물 | (4-Chloroquinazolin-6-yl)methanol | HCID 57469640 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | 4-Chloroquinazoline-6-carbaldehyde | HCID 57469639 | 88% |
반응 단계
To a solution of 4-chloroquinazoline-6yl methanol (3.5 g, 0.018 mol) in dry CH2Cl2 (100 mL) was added Dess-Martin periodinane (8.4 g, 0.019 mol) and stirred at RT for 30 min. The reaction mixture was washed with 10% aqueous NaHCO3 (75 mL), water, brine and dried. The solvent was removed under vacuum to give 4-chloroquinazoline-6-carboxaldehyde (3 g, 88%) as pale yellow solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08106214B2 |
| 출처 데이터셋 | uspto-grants-2012_01 |
| ORD ID | ord-9184dab4e007418a8605ef25bf6bb5d8 |
| 출처 메모 | uspto-grants-2012_01 |