6-(Trifluoromethyl)pyridine-2-carboxylic acid → HCID 25154228, 화합물

HRID 425826노트

반응식

HRID 425826 반응식
[NH2:1][CH2:2][C@H:3]1[N:10]([C:11]([C:13]2[N:14]=[C:15]([CH3:25])[S:16][C:17]=2[C:18]2[CH:19]=[C:20]([CH3:24])[CH:21]=[CH:22][CH:23]=2)=[O:12])[CH2:9][C@H:8]2[C@@H:4]1[CH2:5][CH:6]([CH3:26])[CH2:7]2.[F:27][C:28]([F:39])([F:38])[C:29]1[N:34]=[C:33]([C:35](O)=[O:36])[CH:32]=[CH:31][CH:30]=1>>[CH3:26][CH:6]1[CH2:5][C@H:4]2[C@H:8]([CH2:9][N:10]([C:11]([C:13]3[N:14]=[C:15]([CH3:25])[S:16][C:17]=3[C:18]3[CH:19]=[C:20]([CH3:24])[CH:21]=[CH:22][CH:23]=3)=[O:12])[C@@H:3]2[CH2:2][NH:1][C:35]([C:33]2[CH:32]=[CH:31][CH:30]=[C:29]([C:28]([F:39])([F:27])[F:38])[N:34]=2)=[O:36])[CH2:7]1

참가 물질

3

반응물 2

HCID 147614536-(Trifluoromethyl)pyridine-2-carboxylic acidHCID 59411601[(1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]oct-3-yl]-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

생성물 1

HCID 25154228HCID 25154228, 화합물

실험 절차

prepared by reaction of [(1S,2S,5R)-2-aminomethyl-7-methyl-3-aza-bicyclo[3.3.0]oct-3-yl]-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 6-trifluoromethyl-pyridine-2-carboxylic acid.

출처 및 근거

ORD 기록
ord-50bf033b96b445bc970ebfe4bfd94e5d
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106215B2

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