2-Amino-5-m-tolyl-thiazole-4-carboxylic acid → 6-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-(1S,2S,5R)-{7-methyl-3-[2-amino-5-(3-methyl-phenyl)-thiazole-4-carbonyl]-3-aza-bicyclo[3.3.0]oct-2-ylmethyl}-amide

HRID 425876노트

반응식

[CH3:1][CH:2]1[CH2:9][C@H:8]2[C@H:4]([CH2:5][NH:6][C@@H:7]2[CH2:10][NH:11][C:12]([C:14]2[N:21]3[C:17]([S:18][CH:19]=[CH:20]3)=[N:16][C:15]=2[CH3:22])=[O:13])[CH2:3]1.[NH2:23][C:24]1[S:25][C:26]([C:32]2[CH:37]=[CH:36][CH:35]=[C:34]([CH3:38])[CH:33]=2)=[C:27]([C:29](O)=[O:30])[N:28]=1>>[CH3:1][CH:2]1[CH2:9][C@H:8]2[C@H:4]([CH2:5][N:6]([C:29]([C:27]3[N:28]=[C:24]([NH2:23])[S:25][C:26]=3[C:32]3[CH:37]=[CH:36][CH:35]=[C:34]([CH3:38])[CH:33]=3)=[O:30])[C@@H:7]2[CH2:10][NH:11][C:12]([C:14]2[N:21]3[C:17]([S:18][CH:19]=[CH:20]3)=[N:16][C:15]=2[CH3:22])=[O:13])[CH2:3]1

참가 물질

반응물 2

HCID 532717422-Amino-5-m-tolyl-thiazole-4-carboxylic acid

HCID 594116326-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-[(1S,2S,5R)-7-methyl-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

생성물 1

HCID 251541146-Methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-(1S,2S,5R)-{7-methyl-3-[2-amino-5-(3-methyl-phenyl)-thiazole-4-carbonyl]-3-aza-bicyclo[3.3.0]oct-2-ylmethyl}-amide

실험 절차

prepared by reaction of 6-methyl-imidazo[2,1-b]thiazole-5-carboxylic acid-[(1S,2S,5R)-7-methyl-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide with 2-amino-5-(3-methyl-phenyl)-thiazole-4-carboxylic acid.

출처 및 근거

ORD 기록: ord-87cf84c85f8a4393af9c657b28938d07
출처 데이터셋: uspto-grants-2012_01
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08106215B2

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