2,3-Dihydro-1-benzofuran-4-carboxylic acid → 2,3-Dihydro-benzofuran-4-carboxylic acid-(1S,2S,5R)-[7,7-difluoro-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

HRID 425879

반응식

HRID 425879 반응식
[NH2:1][CH2:2][C@H:3]1[N:10]([C:11]([C:13]2[N:14]=[C:15]([CH3:25])[S:16][C:17]=2[C:18]2[CH:19]=[C:20]([CH3:24])[CH:21]=[CH:22][CH:23]=2)=[O:12])[CH2:9][C@H:8]2[C@@H:4]1[CH2:5][C:6]([F:27])([F:26])[CH2:7]2.[O:28]1[C:32]2=[CH:33][CH:34]=[CH:35][C:36]([C:37](O)=[O:38])=[C:31]2[CH2:30][CH2:29]1>>[F:26][C:6]1([F:27])[CH2:5][C@H:4]2[C@H:8]([CH2:9][N:10]([C:11]([C:13]3[N:14]=[C:15]([CH3:25])[S:16][C:17]=3[C:18]3[CH:19]=[C:20]([CH3:24])[CH:21]=[CH:22][CH:23]=3)=[O:12])[C@@H:3]2[CH2:2][NH:1][C:37]([C:36]2[CH:35]=[CH:34][CH:33]=[C:32]3[O:28][CH2:29][CH2:30][C:31]=23)=[O:38])[CH2:7]1

참가 물질

3

반응물 2

HCID 187874442,3-Dihydro-1-benzofuran-4-carboxylic acidHCID 59411607(1S,2S,5R)-(2-aminomethyl-7,7-difluoro-3-aza-bicyclo[3.3.0]-oct-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone

생성물 1

HCID 251541542,3-Dihydro-benzofuran-4-carboxylic acid-(1S,2S,5R)-[7,7-difluoro-3-(2-methyl-5-m-tolyl-thiazole-4-carbonyl)-3-aza-bicyclo[3.3.0]oct-2-ylmethyl]-amide

실험 절차

prepared by reaction of (1S,2S,5R)-(2-aminomethyl-7,7-difluoro-3-aza-bicyclo[3.3.0]-oct-3-yl)-(2-methyl-5-m-tolyl-thiazol-4-yl)-methanone with 2,3-dihydro-benzofuran-4-carboxylic acid.

출처 및 근거

ORD 기록
ord-added624010c47919da8acc8059c4459
출처 데이터셋
uspto-grants-2012_01
특허 번호
US08106215B2

연결된 노트

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